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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
31.82
Human Site:
S542
Identified Species:
50
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S542
V
G
L
Q
Y
K
K
S
Y
D
D
A
E
S
L
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S550
V
G
L
Q
Y
K
K
S
Y
D
D
A
K
S
L
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S536
V
G
L
Q
Y
K
K
S
Y
D
D
A
E
S
L
Dog
Lupus familis
XP_534241
2041
231068
S960
V
G
L
Q
Y
K
K
S
Y
D
D
A
E
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S530
V
G
L
Q
Y
K
K
S
Y
D
D
A
E
S
L
Rat
Rattus norvegicus
P41516
1526
173202
N519
V
G
L
Q
Y
K
K
N
Y
E
D
E
D
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S845
V
G
L
Q
Y
K
K
S
Y
E
D
A
E
S
L
Chicken
Gallus gallus
O42131
1627
183228
S547
V
G
L
Q
Y
K
K
S
Y
E
D
P
E
S
L
Frog
Xenopus laevis
NP_001082502
1579
178601
N519
V
G
L
Q
Y
K
K
N
Y
D
D
N
E
S
L
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
S541
L
G
L
Q
Y
K
K
S
Y
D
D
P
E
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
L448
E
G
D
S
A
K
S
L
A
V
S
G
L
G
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
L521
D
K
Y
G
V
F
P
L
R
G
K
L
L
N
V
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
D449
F
K
A
Q
S
Q
L
D
K
K
C
H
T
S
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S474
S
L
A
L
A
G
R
S
V
L
G
N
N
Y
C
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
L429
R
I
T
N
Y
P
K
L
E
D
A
N
K
A
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
93.3
100
100
N.A.
100
73.3
N.A.
93.3
86.6
86.6
86.6
N.A.
13.3
N.A.
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
100
93.3
93.3
93.3
N.A.
20
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
14
0
14
0
0
0
7
0
7
40
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
7
% C
% Asp:
7
0
7
0
0
0
0
7
0
54
67
0
7
0
0
% D
% Glu:
7
0
0
0
0
0
0
0
7
20
0
7
54
0
0
% E
% Phe:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
74
0
7
0
7
0
0
0
7
7
7
0
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
14
0
0
0
74
74
0
7
7
7
0
14
0
7
% K
% Leu:
7
7
67
7
0
0
7
20
0
7
0
7
14
0
67
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
14
0
0
0
20
7
7
0
% N
% Pro:
0
0
0
0
0
7
7
0
0
0
0
14
0
0
0
% P
% Gln:
0
0
0
74
0
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
0
0
7
0
7
0
0
0
0
0
0
% R
% Ser:
7
0
0
7
7
0
7
60
0
0
7
0
0
74
0
% S
% Thr:
0
0
7
0
0
0
0
0
0
0
0
0
7
0
0
% T
% Val:
60
0
0
0
7
0
0
0
7
7
0
0
0
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
74
0
0
0
67
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _